Version-4 of the Goddard Earth Observing System (GEOS-4) General Circulation Model (GCM) was employed to assess the influence of changes in aerosols on the regional circulation, ambient temperatures, and precipitation in four selected regions: India and Africa (current focus), as well as North and South America. Ensemble-simulations were carried out with the GCM to assess the aerosol direct and indirect effects, hereafter ADE and AIE. Each simulation started from initial conditions of May 1and was integrated through June-July-August of each of the six years: 1982-1987, to provide a 6-ensemble set. In the first set, called the baseline experiment (#1); each simulation used the climatological aerosols. The next two experiments (#2 and 3) had two sets of simulations each: one with 2X and another with 1/2X the climatological aerosols over the selected regions. In experiment#2, the anomaly regions were advectively restricted (AR) by prescribing the large-scale prognostic fields outside the aerosol anomaly regions. In experiment#3, the anomaly regions were advectively Interactive (AI) which implies a normal GCM integration but with the aforestated aerosol anomalies. Intercomparisons of circulation, diabatic heating, and precipitation fields among AR and AI simulations showed huge disparities. This led to the conclusion that AR assumption, commonly invoked in several regional climate studies, gives highly spurious results. Two more experiments (#4&5) were performed in which ADE and AIE were activated one at a time in the AI mode. The results showed that ADE and AIE work in concert to make the joint influences larger than the individual. Moreover, ADE and AIE influences were vastly different for Indian and Africa regions showing clearly that there are no general rules for the climate response to aerosol forcing among different regions. This suggests an imperative need to include rationally both ADE and AIE in the climate models. Even if some of the specific details of our inferences were model dependent, the inference that regional aerosols strongly interact and affect the global circulation will remain valid.